Herbal Products for Progressive Familial Intrahepatic Cholestasis

ABSTRACT

Progressive familial intrahepatic cholestasis is also known as BYLER’S DISEASE is a congenital disease which is rare. It is an progressive disease normally from childhood but symptoms may start appearing by the age of two and rarely in adolescence. Its estimated incidence is 1 in 50,000 or 1 in 100000. Both men and women are equally affected. It results from Gene mutation and this condition gets worse with time. This condition is inherited as an autosomal recessive pattern. Let’s read about its causes, symptoms and management in this article.

INTRODUCTION

As the name says Progressive – gradual developing, Familial – genetic (Same family genes), Intrahepatic- inside the liver, Cholestasis – Problem with excretion of bile. It is due to inherited molecular defects. In this condition the child is not able to drain the bile from the liver which develops gradually Also the liver cells find it difficult to produce and secrete bile. Due to this there is accumulation of the bile in the liver and body is not able to absorb fats and vitamins which leads to vitamin deficiency and more of waste material in bloodstream.There are FIVE types of progressive familial intrahepatic cholestasis.PFIC1, PFIC2, PFIC3, PFIC4, PFIC5. In these PFIC1, PFIC2, PFIC3 is the most seen one and PFIC4, PFIC5 are the rarest.

Causes

The main genes involved in this are

• ATP8B1 gene mutation – PFIC1
• ABCB11 gene mutation – PFIC2
• ABCB4 gene mutation – PFIC3
• TJP2 gene mutation – PFIC4
• NR1H4 gene mutation – PFIC5

SIGN AND SYMPTOMS

• Jaundice (Yellowish discoloration of skin and conjunctiva)
• Pruritus (Itching severe)
• Poor weight gain
• Slow growth
• General debility
• Portal hypertension
• Splenomegaly (Enlarged spleen)
• Hepatomegaly (Enlarged liver)
• Deafness
• Malabsorption
• Pancreatitis
• Edema (Peripheral)
• Low levels of vitamins A, D, E, K
• Short stature
• Diarrhea

DIAGNOSIS

Physical examination / Clinical examination Liver biopsies Analysis of biliary lipid composition Genetic panel testing Ultrasonography

MANAGEMENT

AS PER MODERN: There is no specific cure but can be treated as following Diet

• Vitamin supplements A, D, E, K
• Anti histamines
• Bile drainage
• Sedatives
• Cholangiography
• Liver transplantation

AS PER AYURVEDIC OVERVIEW

Ayurveda is an ancient healing science which is around 5000 years old. Ayurveda treats the patients on the basis of their prakriti, dosha, dhatu etc. factors and with the help of the natural herbs, yoga and diet. In the classics liver disorders are linked to pitta dosha, so the imbalance of the pitta dosha is the cause for liver disorders (Yakrit vikara). The factors leading to pitta dushti are intake of spicy, oily, heavy foods. Suppression of natural urges etc.. Which may lead to toxicity in the body.

DIAGNOSIS

• Darshana (Direct perception)
• Sparshana (Touch perception)
• Prashan (Questioning)

MANAGEMENT

• Diet
• Purificatory measures
• Herbal remedies

Diet

Intake of fresh fruits and vegetables, legumes, liquid diet. Avoid spicy, hot, heavy foods and carbonated drinks. Avoid alcohol and Smoking.

Purificatory measures

Deepan, Pachan, Virechan and Rakta mokshan according to the condition of the patient.

Rx in Ayurveda

Usage of drugs such as Punarnava mandoor, Haridra, Amla, kalmegh etc. These drugs are very beneficial and have hepatoprotective properties.

PUNARNAVA MANDOOR

Punarnava mandoor is the most effective herb in liver disorders, it not only purifies the liver but also maintains the proper functioning of the liver.

HARIDRA

It is a magical herb which has anti inflammatory, antibiotic and antioxidant properties. It prevents fat accumulation in the liver, reduces liver damage.

AMLA

Amla has antioxidant properties, it balances all the doshas, It has restorative, anti inflammatory properties also acts as hair and live tonic and aids digestion.

KALMEGH

Kalmegh is another herb for the management of Liver disease, It has hepatoprotective properties as well as anti inflammatory and has blood purifying properties.

HERBAL REMEDIES FOR PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS BY PLANET AYURVEDA.

Planet ayurveda is an ayurvedic clinic which has its own manufacturing unit. The products manufactured here are 100% natural and safe for consumption. It is GMP and ISO certified which manufactures classical as well as patent medicines. It deals with natural ways of healing through herbs and diet. It manufactures the medicine in different forms such as tablets, capsules, Powders, Tea and also cosmetic products. The company was established in 2002 and has been serving for more than 20 years. They are treating all conditions on the basis of basic ayurvedic principles specially the chronic disorders.

Products List

1. Yakrit Plihantak Churna
2. Sanjivani Vati
3. Kalmegh Ghan Vati
4. Bhumi amla Swaras
5. Liv Support

Product Description

1. YAKRIT PLIHANTAK CHURNA

It is a patent ayurvedic medicine by planet ayurveda in powder form which includes Bhumi Amla (Phyllanthus niruri), bhringraj (Eclipta alba), kalmegh (Andrographis paniculata), Sharpunkha (Tephrosia purpurea) etc.. It has hepatoprotective properties, it is useful in fatty liver, liver cirrhosis and liver damage. It relieves inflammation and regenerates new liver cells. It promotes healthy spleen and liver and also promotes overall health.

DOSAGE – 1 tablespoon taken twice daily with plain water.

2. SANJIVANI VATI

It is an ancient ayurvedic medicine which is also manufactured by planet ayurveda in tablet form which consists of Haritaki(Terminalia chebula), Amalaki (Emblica officinalis), Vacha (Acorus calamus), Vidanga (Emblica ribes), Guduchi (Tinospora cordifolia) etc.. It also has Hepatoprotective property which helps in strengthening the liver and spleen. It has anti inflammatory , anti-oxidant properties. It is very effective in digestion related disorders.

DOSAGE – Take 2 tablets twice daily.

3. KALMEGH GHAN VATI

Kalmegh ghan vati is a classical ayurvedic medicine manufactured by planet Ayurveda in tablet form which includes kalmegh (Andrographis paniculata) which is useful in balancing the pitta dosha. It acts as Rasayana, helps in liver detoxification, supports and strengthens the liver, It helps in digestion and maintains healthy liver.

DOSAGE – Take 2 tablets twice a day.

4. BHUMI AMLA SWARAS

Bhumi Amla Swaras is very beneficial herb which is manufactured by planet ayurveda consist of bhumi amla (Phyllanthus niruri), it is very beneficial in liver and kidney disorders such as kidney stones, It maintains healthy skin, useful in anemic patients and it pacifies kapha and pitta dosha.

DOSAGE – 2 tablespoons taken twice a day.

5. LIV SUPPORT

Liv support is a patent herbal medicine which is manufactured by planet ayurveda in capsule form which includes Bhringraj (Eclipta alba), kalmegh (Andrographis paniculata), and saral (Pinus roxburghii) etc. It is used for liver disorders such as liver cirrhosis, liver damage, liver failure, and also inches digestion. It acts as an antioxidant and has Hepatoprotective properties.

DOSAGE- 1 capsule twice daily.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604

CONCLUSION

Progressive familial intrahepatic cholestasis is a genetic and congenital disease. It develops gradually inside the liver. It is a rare disease which can lead to liver failure. According to ayurveda, Yakrit (Liver) Vikara is due to pitta imbalance which can be treated by ayurvedic remedies as mentioned above. It mainly focuses on removing the toxins out of the body and stabilizes the dosha. You can find the herbal remedies and treatment for the condition at www.planetayurveda.com