ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is a term used to describe a diverse set of juvenile autosomal recessive diseases that affect bile production and manifest as cholestasis of hepatocellular origin. People with conditions like portal hypertension, hepatosplenomegaly, jaundice, or acute itching are specifically targeted. This illness primarily results in cirrhosis and an urgent need for a liver transplant. Progressive…